Unique seeding profiles and prion-like propagation of synucleinopathies are highly dependent on the host in human α-synuclein transgenic mice
Grace M. Lloyd, Zachary A. Sorrentino, Stephan Quintin, Kimberly-Marie M. Gorion, Brach M. Bell, Giavanna Paterno, Brooke Long, Stefan Prokop, Benoit I. Giasson
Topics & Concepts
SynucleinopathiesDementia with Lewy bodiesBiologyAlpha-synucleinFibrilAmyloid (mycology)Genetically modified mouseNeurodegenerationProtein aggregationHuman brainProtein foldingPathologyAmyloidosisTransgeneCell biologyNeuroscienceDementiaParkinson's diseaseDiseaseGeneticsMedicineGeneBotanyAlzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingParkinson's Disease Mechanisms and Treatments