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In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR

Jérémie Charbord, Lipeng Ren, Rohit B. Sharma, Anna Johansson, Rasmus Ågren, Lianhe Chu, Dominika Tworus, Nadja Schulz, Pierre Charbord, Andrew F. Stewart, Peng Wang, Laura Alonso, Olov Andersson

2021Nature Metabolism39 citationsDOIOpen Access PDF

Topics & Concepts

Cell biologyZebrafishCell growthCell cycleCellEffectorATF6Transcription factorChemistryBiologyPI3K/AKT/mTOR pathwayUnfolded protein responseSignal transductionEndoplasmic reticulumBiochemistryGenePancreatic function and diabetesMetabolism, Diabetes, and CancerEndoplasmic Reticulum Stress and Disease
In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR | Litcius