An intramolecular photoswitch can significantly promote photoactivation of Pt(<scp>iv</scp>) prodrugs
Zhiqin Deng, Cai Li, Shu Chen, Qiyuan Zhou, Zoufeng Xu, Zhigang Wang, Houzong Yao, Hajime Hirao, Guangyu Zhu
Abstract
efficiently accumulated in the mitochondria and induced apoptosis without causing genomic DNA damage to overcome drug resistance. This work presents a new approach to develop highly effective prodrugs containing intramolecular photoswitches for potential medical applications.
Topics & Concepts
PhotoswitchProdrugPhotocatalysisIntramolecular forceChemistryPhotochemistryStereochemistryCatalysisBiochemistryPhotochromic and Fluorescence ChemistryAdvanced biosensing and bioanalysis techniquesAdvanced Photocatalysis Techniques