Photoredox-Catalyzed Decarboxylative Cross-Coupling of α-Amino Acids with Nitrones
Heng‐Hui Li, Jia‐Qi Li, Xiao Zheng, Pei‐Qiang Huang
Abstract
A decarboxylative cross-coupling reaction of α-amino acids with nitrones via visible-light-induced photoredox catalysis has been established for easy access to β-amino hydroxylamines and vicinal diamines with structural diversity, which is featured with simple operation, mild conditions, readily available α-amino acids, and a broad scope of nitrone substrates. The application of this protocol can furnish efficient synthetic strategies for some valuable vicinal diamine-containing molecules.
Topics & Concepts
ChemistryVicinalPhotoredox catalysisCatalysisAmino acidCombinatorial chemistryNitroneMoleculeCoupling reactionOrganic chemistryPhotocatalysisCycloadditionBiochemistryRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods