Peptide Modified Albumin–Paclitaxel Nanoparticles for Improving Chemotherapy and Preventing Metastasis
Ying Fu, Shuyan Yang, Yuning Liu, Jian Liu, Qizhi Wang, Fengyan Li, Xiuzhuan Shang, Yuou Teng, Na Guo, Peng Yu
Abstract
Metastasis and recurrence are the main causes of death in cancer patients; however, there are few medicines that can inhibit tumor growth and metastasis at the same time. In this work, a novel nano-drug delivery system (NDDS) based on targeting ligand modified albumin is reported. The hydrophobic drug (paclitaxel) induces albumin self-assembly after treatment of albumin with l-cysteine, forming drug-loaded nanoparticles with a size of 100-200 nm. Importantly, the albumin nanoparticles display enhanced antitumor efficacy against tumor growth/lung metastasis in 4T1 bearing nude mice and prevention of lung metastasis in a B16-F10 model. This study provides a facile method for hydrophobic chemo-drugs loaded albumin nanoparticles preparation and a promising chemotherapy with effective tumor growth inhibition and metastasis prevention.