Efg1 and Cas5 Orchestrate Cell Wall Damage Response to Caspofungin in Candida albicans
Kang Xiong, Chang Su, Qiangqiang Sun, Yang Lü
Abstract
immunoprecipitation in the presence or absence of caspofungin. Importantly, Efg1 and Cas5 bind to some caspofungin-responsive gene promoters to coordinately activate their expression. Thus, we demonstrate that Efg1, together with Cas5, controls the transcriptional response to cell wall stress induced by caspofungin.
Topics & Concepts
EchinocandinsCaspofunginCandida albicansMicrobiologyBiologyAntifungalAmphotericin BAntifungal resistance and susceptibilityFungal Infections and StudiesPneumocystis jirovecii pneumonia detection and treatment