Photoinduced cerium-catalyzed C–H acylation of unactivated alkanes
Jing Cao, Joshua L. Zhu, Karl A. Scheidt
Abstract
)-H bonds using bench-stable acyl azolium reagents under mild and operationally-friendly conditions. This reaction exhibits excellent generality, accommodating a wide range of feedstock chemicals such as cycloalkanes and acyclic compounds as well as facilitating the late-stage functionalization of pharmaceuticals. We demonstrate further applications of our strategy with a three-component radical relay reaction and an enantioselective N-heterocyclic carbene (NHC) and cerium dual-catalyzed reaction.
Topics & Concepts
CeriumAcylationCatalysisChemistryRealmOrganic chemistryCombinatorial chemistryPolitical scienceLawCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSynthesis and Catalytic Reactions