A purified fraction of polysaccharides from the fruits of <i>Lycium barbarum</i> L. improves glucose homeostasis and intestinal barrier function in high-fat diet-fed mice
Wangting Zhou, Peiyun Liu, Weiqi Xu, Linwu Ran, Yamei Yan, Lu Lu, Xiaoxiong Zeng, Youlong Cao, Jia Mi
Abstract
. The results of fecal transplantation experiments, transferring of microbiota from LBPs-4-fed donor mice to HFD-fed recipient mice, validated the cause-effect relationship between LBPs-4-evoked changes in the gut microbiota and improvement of glucose homeostasis and intestinal barrier function. Collectively, these findings suggested that LBPs-4 might be developed as promising prebiotics to improve glucose metabolism and gut health.
Topics & Concepts
LyciumPolysaccharideBarrier functionGlucose homeostasisHomeostasisFunction (biology)Diet-induced obeseChemistryEndocrinologyInternal medicineBiologyBiochemistryCell biologyDiabetes mellitusMedicineInsulin resistancePathologyAlternative medicineMicrobial Metabolites in Food BiotechnologyPolysaccharides and Plant Cell WallsPolysaccharides Composition and Applications