Gastrointestinal Zygomycosis in a Preterm Neonate Associated With Contaminated Probiotics
Matthew J. Bizzarro, David R. Peaper, Raffaella Morotti, George Paci, Michelle Rychalsky, John M. Boyce
Abstract
A neonate of 29 weeks' gestation who received probiotics developed clinical signs suggesting surgical necrotizing enterocolitis. A specimen of resected ileum revealed fungal forms within the bowel wall. Rhizopus oryzae was detected via DNA sequencing from probiotic powder and tissue specimens from the infant. To our knowledge, this is the first report linking gastrointestinal zygomycosis to the administration of contaminated probiotics.
Topics & Concepts
ZygomycosisNecrotizing enterocolitisRhizopus oryzaeProbioticGastrointestinal tractMedicineRhizopusIleumGestationEnterocolitisMucormycosisMicrobiologyGastroenterologyBiologyInternal medicinePathologyPregnancyDermatologyAntifungalAmphotericin BFood scienceBacteriaGeneticsFermentationAntifungal resistance and susceptibilityProbiotics and Fermented FoodsEnterobacteriaceae and Cronobacter Research