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Molecular recognition of peptides and proteins by cucurbit[<i>n</i>]urils: systems and applications

Lilyanna Armstrong, Sarah L. Chang, Nia Clements, Zoheb Hirani, Lauren B. Kimberly, Keturah Odoi-Adams, Paolo Suating, Hailey F. Taylor, Sara A. Trauth, Adam R. Urbach

2024Chemical Society Reviews36 citationsDOIOpen Access PDF

Abstract

several distinct mechanisms, which are supported by extensive thermodynamic and structural studies in aqueous media. The commercial availability, low cost, high stability, and biocompatibility of these synthetic receptors has led to the development of myriad applications. This comprehensive review compiles the molecular recognition studies and the resulting applications with the goals of providing a valuable resource to the community and inspiring the next generation of innovation.

Topics & Concepts

Molecular recognitionChemistryAqueous solutionSelectivityReceptorPeptideSequence (biology)Combinatorial chemistryAmino acidComputational biologyBiochemistryMoleculeBiologyOrganic chemistryCatalysisSupramolecular Chemistry and ComplexesMass Spectrometry Techniques and ApplicationsMolecular Sensors and Ion Detection
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