Discovery of new pyrimido[5,4-c]quinolines as potential antiproliferative agents with multitarget actions: Rapid synthesis, docking, and ADME studies
Ramadan Ahmed Mekheimer, Samar M. R. Allam, Mariam A. Al‐Sheikh, Moustafa S. Moustafa, Saleh Mohammed Al‐Mousawi, Yaser A. Mostafa, Bahaa G. M. Youssif, Hesham A. M. Gomaa, Alaa M. Hayallah, Mohamed Abdel‐Aziz, Kamal Usef Sadek
Topics & Concepts
ChemistryADMECamptothecinQuinolineStereochemistryCytotoxicityIC50Docking (animal)PharmacophoreCombinatorial chemistryIn vitroBiochemistryOrganic chemistryMedicineNursingCancer therapeutics and mechanismsQuinazolinone synthesis and applicationsSynthesis and biological activity