Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities
Asmaa Sakr, Samar Rezq, Samy M. Ibrahim, Eman Soliman, Mohamed M. Baraka, Damián G. Romero, Hend Kothayer
Abstract
) support their potential role as anti-inflammatory agents.
Topics & Concepts
CelecoxibAcetamideIbuprofenChemistryAnti-inflammatoryPharmacologyIn vivoIndole testSelectivityAnalgesicDocking (animal)StereochemistryBiochemistryMedicineOrganic chemistryBiologyNursingBiotechnologyCatalysisInflammatory mediators and NSAID effectsQuinazolinone synthesis and applicationsSynthesis and biological activity