Usefulness of MRI-based radiomic features for distinguishing Warthin tumor from pleomorphic adenoma: performance assessment using T2-weighted and post-contrast T1-weighted MR images
Lorenzo Faggioni, Michela Gabelloni, Fabrizio De Vietro, Jessica Frey, Vincenzo Mendola, Diletta Cavallero, Rita Borgheresi, Lorenzo Tumminello, Jorge Eduardo Shortrede, Riccardo Morganti, Veronica Seccia, Francesca Coppola, Dania Cioni, Emanuele Neri
Abstract
Purpose: Differentiating Warthin tumor (WT) from pleomorphic adenoma (PA) is of primary importance due to differences in patient management, treatment and outcome. We sought to evaluate the performance of MRI-based radiomic features in discriminating PA from WT in the preoperative setting. Methods: We retrospectively evaluated 81 parotid gland lesions (48 PA and 33 WT) on T2-weighted (T2w) images and 52 of them on post-contrast fat-suppressed T1-weighted (pcfsT1w) images. All MRI examinations were carried out on a 1.5-Tesla MRI scanner, and images were segmented manually using the software ITK-SNAP (www.itk-snap.org). Results: The most discriminative feature on pcfsT1w images was GLCM_InverseVariance, yielding area under the curve (AUC), sensitivity and specificity of 0.9, 86 % and 87 %, respectively. Skewness was the feature extracted from T2w images with the highest specificity (88 %) in discriminating WT from PA. Conclusion: Radiomic analysis could be an important tool to improve diagnostic accuracy in differentiating PA from WT.