Bis-chalcone polyphenols with potential preventive and therapeutic effects on PD: Design, synthesis and in vitro disaggregation activity against α-synuclein oligomers and fibrils
Bing Jiang, Feng Han, Ming-Huan Lü, Zhenping Wang, Wei Liu, Yunxiao Zhang, Ji Xu, Rui-Jun Li
Topics & Concepts
ChemistryFibrilProteostasisChalconeMonomerBiophysicsProtein aggregationSmall moleculeIn vitroStereochemistryBiochemistryOrganic chemistryPolymerBiologyParkinson's Disease Mechanisms and TreatmentsBiochemical and biochemical processesGinkgo biloba and Cashew Applications