Impact of B-Glucan Against Ehrlich Ascites Carcinoma Induced Renal Toxicity in Mice
Ahmed Flayyih Hasan, Azhar Azher Mohammed Al-Ankoshy, Azhar Azher Mohammed Al-Ankoshy, Alaa Saadi Abbood, Ali Ghazi Dulimi, Hiba Muhammed Al-Khuzaay, Eslam Ahmed Elsaedy, Ehab Tousson
Abstract
<p>Several studies have been focused on identifying alternative medicines for the treatment of cancer. This study aimed to investigate the impact of B-Glucans extract (BG) against Ehrlich Ascites Carcinoma (EAC) induced toxicity and tissue damage in kidney. A total of 40 mice were assigned randomly to four groups (G1, control; G2, B-Glucans (75 mg/kg bw/day) orally for 2 weeks; G3, EAC and G4, EAC + BG). Current results revealed, EAC induced significant elevation in urea, creatinine, potassium (k<sup>+</sup>), chloride (Cl<sup>-</sup>) ions, kidney injury and significant decrease in sodium (Na<sup>+</sup>) and calcium (Ca<sup>++</sup>) ions when compared to B-glucans and control groups. Conversely, EAC + B-glucans modulate these changes and improved the renal functions and structure. EAC induced renal dysfunction and B-Glucans has the ability to improve renal functions. We can conclude that; BG could be used as an adjuvant therapy for kidney in ascites of hepatocellular carcinoma, <em>Schistosoma</em> and hepatitis.</p>