Bedaquiline Resistance after Effective Treatment of Multidrug-Resistant Tuberculosis, Namibia
Gunar Günther, Lusia Mhuulu, Azaria Diergaardt, Viola Dreyer, Maria Moses, Kaarna Anyolo, Nunurai Ruswa, Mareli Claassens, Stefan Niemann, Emmanuel Nepolo
Abstract
Bedaquiline is currently a key drug for treating multidrug-resistant or rifampin-resistant tuberculosis. We report and discuss the unusual development of resistance to bedaquiline in a teenager in Namibia, despite an optimal background regimen and adherence. The report highlights the risk for bedaquiline resistance development and the need for rapid drug-resistance testing.
Topics & Concepts
BedaquilineTuberculosisMedicineMultiple drug resistanceDrug resistanceRegimenIntensive care medicineInternal medicineBiologyMicrobiologyMycobacterium tuberculosisPathologyTuberculosis Research and EpidemiologyPneumocystis jirovecii pneumonia detection and treatmentDiagnosis and treatment of tuberculosis