A Novel XRE-Type Regulator Mediates Phage Lytic Development and Multiple Host Metabolic Processes in Pseudomonas aeruginosa
Xiang Long, Xiaolong Wang, Daqing Mao, Weihui Wu, Yi Luo
Abstract
This work elucidates the novel roles of a putative XRE family TR, LfsT, in the intricate regulatory systems of P. aeruginosa . We found that LfsT bound directly to the core promoter regions upstream of the start codons of numerous genes involved in various processes, including phage infection, FA metabolism, SPD transport, and the T3SS, regulating as the repressor or activator.
Topics & Concepts
BiologyLytic cyclePseudomonas aeruginosaProphageGeneticsGeneElectrophoretic mobility shift assayRepressorTranscriptional regulationLysogenic cycleBacteriophageMicrobiologyTranscription factorBacteriaEscherichia coliVirusBacteriophages and microbial interactionsBacterial Genetics and BiotechnologyAntibiotic Resistance in Bacteria