OASL Triggered by Novel Goose Astrovirus via ORF2 Restricts Its Replication
Dan Ren, Tuofan Li, Xinyu Zhang, Xiaohui Yao, Wei Gao, Quan Xie, Jianjun Zhang, Hongxia Shao, Zhimin Wan, Aijian Qin, Jianqiang Ye
Abstract
Astroviruses cause gastroenteritis and encephalitis in human, and nephritis, hepatitis, and gout disease in poultry. However, the host immune response activated by astrovirus is mostly unknown. Here, we found that a novel goose astrovirus, GAstV-GD, and its ORF2 protein could efficiently induce a high level of OASL in vitro and in vivo, which could feed back to restrict the replication of GAstV-GD, revealing novel innate molecules triggered by astroviruses and highlighting that the ORF2 of GAstV-GD and OASL can be potential antiviral targets for astroviruses.
Topics & Concepts
BiologyVirologyAstrovirusGooseViral replicationEncephalitisVirusInnate immune systemImmune systemRotavirusGeneticsPaleontologyViral gastroenteritis research and epidemiologyAnimal Virus Infections StudiesVirus-based gene therapy research