Discovery of novel 6-(piperidin-1-ylsulfonyl)-2H-chromenes targeting α-glucosidase, α-amylase, and PPAR-γ: Design, synthesis, virtual screening, and anti-diabetic activity for type 2 diabetes mellitus
Hamdy Khamees Thabet, Moustafa S. Abusaif, Mohd Imran, Mohamed H. Helal, Saleh I. Alaqel, Ahmed Alshehri, Abida Ash Mohd, Yousry A. Ammar, Ahmed Ragab
Topics & Concepts
Virtual screeningType 2 Diabetes MellitusAmylasePeroxisome proliferator-activated receptorMedicineDiabetes mellitusPharmacologyChemistryComputational biologyEndocrinologyInternal medicineEnzymeDrug discoveryBiochemistryReceptorBiologyEnzyme function and inhibitionNatural Antidiabetic Agents StudiesEnzyme Catalysis and Immobilization