Anti-Inflammatory Effects and Mechanisms of Pudilan Antiphlogistic Oral Liquid
Gang Tian, Xiaoqun Gu, Kaifan Bao, Xuerui Yu, Yuheng Zhang, Yifan Xu, Jie Zheng, Min Hong
Abstract
experiments clarified that PDL has anti-inflammatory potency by inhibiting PI3K and p38 phosphorylation and activating the NLRP3 inflammasome. Our results suggested that PDL has an efficient and extensive anti-inflammatory effect, and its anti-inflammatory mechanisms may involve multiple inflammatory-associated signaling pathways, including HIF-1- and TNF-mediated pathways and NLRP3 inflammasome activation.
Topics & Concepts
In vivoPharmacologyInflammationTumor necrosis factor alphaAnti-inflammatoryInflammasomeChemistryMedicineImmunologyBiologyBiotechnologyInflammasome and immune disordersFlavonoids in Medical ResearchImmune cells in cancer