<i>Click’n lock</i> : rapid exchange between unsymmetric tetrazines and thiols for reversible, chemoselective functionalisation of biomolecules with on-demand bioorthogonal locking
Katerina Gavriel, Dustin C. A. van Doeselaar, Daniëlle W. T. Geers, Kevin Neumann
Abstract
Click’n lock describes a reaction system capable of switching on-demand from reversible to irreversible click reactions and is based on the chemoselective tetrazine–thiol exchange. Here, click’n lock is applied for dynamic modifications of peptides.
Topics & Concepts
Click chemistryBioorthogonal chemistryTetrazineBiomoleculeChemistryCombinatorial chemistryReactivity (psychology)NanotechnologyOrganic chemistryMaterials scienceMedicinePathologyBiochemistryAlternative medicineClick Chemistry and ApplicationsMonoclonal and Polyclonal Antibodies ResearchChemical Synthesis and Analysis