Neuroimaging Correlates of Cognitive Dysfunction in Adults with Multiple Sclerosis
Maria Petracca, Giuseppe Pontillo, Marcello Moccia, Antonio Carotenuto, Sirio Cocozza, Roberta Lanzillo, Arturo Brunetti, Vincenzo Brescia Morra
Abstract
Cognitive impairment is a frequent and meaningful symptom in multiple sclerosis (MS), caused by the accrual of brain structural damage only partially counteracted by effective functional reorganization. As both these aspects can be successfully investigated through the application of advanced neuroimaging, here, we offer an up-to-date overview of the latest findings on structural, functional and metabolic correlates of cognitive impairment in adults with MS, focusing on the mechanisms sustaining damage accrual and on the identification of useful imaging markers of cognitive decline.
Topics & Concepts
NeuroimagingMultiple sclerosisCognitionNeuroscienceAccrualCognitive impairmentFunctional neuroimagingPsychologyIdentification (biology)MedicineCognitive psychologyPsychiatryBiologyAccountingBotanyBusinessEarningsMultiple Sclerosis Research StudiesLong-Term Effects of COVID-19Alzheimer's disease research and treatments