Combined Exposure to Folate and Lead during Pregnancy and Autistic-Like Behaviors among Canadian Children from the MIREC Pregnancy and Birth Cohort
Joshua D. Alampi, Bruce P. Lanphear, Amanda J MacFarlane, Youssef Oulhote, Joseph M. Braun, Gina Muckle, Tye E. Arbuckle, Jillian Ashley‐Martin, Janice M. Y. Hu, Aimin Chen, Lawrence C. McCandless
Abstract
BACKGROUND: Folic acid (FA) supplementation may attenuate the associations between gestational exposure to certain chemicals and autism or autistic-like behaviors, but to our knowledge, this has not been assessed for lead. OBJECTIVES: ) 677C>T genotype. METHODS: 677C>T genotype using linear regression. RESULTS: ). DISCUSSION: Folate may modify the associations between gestational lead exposure and childhood autistic-like behaviors, suggesting that it mitigates the neurotoxic effects of prenatal lead exposure. https://doi.org/10.1289/EHP14479.
Topics & Concepts
PregnancyCohortLead exposureCohort studyMedicineAutismEnvironmental healthObstetricsPediatricsPsychiatryBiologyInternal medicineCATSGeneticsHeavy Metal Exposure and ToxicityTrace Elements in HealthPregnancy and Medication Impact