Extracellular vesicles deposit <i>PCNA</i> to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration
Qian Lei, Fei Gao, Teng Liu, Wenxiang Ren, Li Chen, Yulin Cao, Wenlan Chen, Shaojun Guo, Qiong Zhang, Weiqun Chen, Hongxiang Wang, Zhichao Chen, Qiubai Li, Yu Hu, An‐Yuan Guo
Abstract
) into recipient AB-MSCs. When tested in therapeutic context, UC-EV-triggered rejuvenation enhanced the regenerative capacities of AB-MSCs in bone formation, wound healing, and angiogenesis. Intravenously injected UC-EVs conferred anti-aging phenotypes including decreased bone and kidney degeneration in aged mice. Our findings reveal that UC-EVs are of high translational value in anti-aging intervention.
Topics & Concepts
Extracellular vesiclesMesenchymal stem cellBone marrowExtracellularVesicleCell biologyDegeneration (medical)PathologyStem cellUmbilical cordBiologyMedicineChemistryAnatomyBiochemistryMembraneExtracellular vesicles in diseaseMicroRNA in disease regulationMesenchymal stem cell research