Soluble Klotho Improves Hepatic Glucose and Lipid Homeostasis in Type 2 Diabetes
Huiying Gu, Wei Jiang, Nan You, Xiaobing Huang, Yuming Li, Xuehui Peng, Rui Dong, Zheng Wang, Yinan Zhu, Ke Wu, Jing Li, Lu Zheng
Abstract
demonstrated that sKL could inhibit the PI3K/AKT/mTORC1 signaling to upregulate peroxisome proliferator-activated receptor α (PPARα) expression by directly interacting with type 1 insulin-like growth factor receptor (IGF1R) in HFD-fed T2D mice. Thus, sKL could improve hepatic glucolipid homeostasis to ameliorate diabetic phenotypes and lipid accumulation and may function as a potential therapeutic target for the treatment of T2D and reduce the risk of NAFLD.
Topics & Concepts
EndocrinologyInternal medicineInsulin resistanceType 2 diabetesNonalcoholic fatty liver diseaseGlucose homeostasisLipid metabolismmTORC1Fatty liverInsulinDownregulation and upregulationBiologyPeroxisome proliferator-activated receptorCarbohydrate metabolismInsulin receptorSteatosisFGF21Diabetes mellitusProtein kinase BReceptorMedicineSignal transductionBiochemistryDiseaseFibroblast growth factorGeneParathyroid Disorders and TreatmentsGenetic Syndromes and ImprintingMetabolism, Diabetes, and Cancer