Crystal Structure and Hirshfeld Surface Analysis of Acetoacetanilide Based Reaction Products
Farid N. Naghiyev, Jonathan Cisterna, Ali N. Khalilov, Abel M. Maharramov, Р.К. Аскеров, Kh. A. Asadov, I. G. Mamedov, Khaver S. Salmanli, Alejandro Cárdenas, Iván Brito
Abstract
We report an unprecedented multicomponent reaction of acetoacetanilide with malononitrile leading to a structurally novel bicyclic product (9) in a high yield. The structure has been confirmed by X-ray crystallography and comparative Hirshfeld surface analysis of 5-cyano-2-hydroxy-2-methyl-N-phenyl-4-(yridine-4-yl)-6-(thiophen-2-yl)-3,4-dihydro-2H-pyran-3-carboxamide 2, 5-cyano-2-hydroxy-2-methyl-6-oxo-N-phenyl-4-(thiophen-2-yl)piperidine-3-carboxamide 4 and 2-(8-amino-7,8a-dicyano-1-imino-4a-methyl-3-oxo-2-phenyl-1,3,4,4a,5,8a-hexahydroisoquinolin-6(2H)-ylidene)-N-phenylacetamide 9.