[Metal–Diphosphine]-Catalyzed Asymmetric Hydrogenation of β-Amido β-Substituted Acrylates: A Practical Literature Overview
Michel Stephan, Marko Jeran, Barbara Mohar
Abstract
Transition-metal-complex-catalyzed asymmetric hydrogenation of archetypal β-amido β-(methyl or phenyl)acrylates (and close derivatives) into the corresponding enantioenriched β-amido propionates is reviewed. The literature reports (including patents) on efficient enantiopure P,P-ligand-enabled catalytic systems─wherein the P,P-ligand is a cis -chelating diphosphine─are juxtaposed under their disclosed testing conditions per substrate along with the scored enantioselectivity. Such a listing clearly reveals their relative performance and constitutes a practical guide to inspire future development.
Topics & Concepts
Enantiopure drugAsymmetric hydrogenationLigand (biochemistry)CatalysisPropionatesSubstrate (aquarium)ChemistryEnantioselective synthesisCombinatorial chemistryChelationMetalChiral ligandTransition metalOrganic chemistryStereochemistryMedicinal chemistryOceanographyReceptorBiochemistryGeologyAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisSurface Chemistry and Catalysis