Development and validation of an UPLC-ESI-MS/MS method for quantification of duvelisib in plasma: application to pharmacokinetic study in rats
Ibrahim A. Darwısh, Nourah Z. Alzoman, Aliyah Almomen, Abdulrahman A. Almehizia, Mohamed W. Attwa, Hany W. Darwish, Ahmed Y. A. Sayed
Abstract
of the drug. The methodology is distinguished by excellent sensitivity, accuracy, and ease of sample pretreatment. Furthermore, it is efficient and has a short run time, which makes it high throughput and accordingly enables faster processing of many samples in clinical laboratories.
Topics & Concepts
ChromatographyDetection limitChemistryProtein precipitationAmmonium formatePharmacokineticsReproducibilityBioanalysisReagentAnalyteAnalytical Chemistry (journal)AcetonitrilePharmacologyMedicinePhysical chemistryChronic Lymphocytic Leukemia ResearchImmunodeficiency and Autoimmune DisordersPI3K/AKT/mTOR signaling in cancer