Radical C–H Sulfonation of Arenes: Its Applications on Bioactive and DNA-Encoded Molecules
Yue Zhang, Shengdi Xia, Wenxia Shi, Bizhen Lin, Xiao‐can Su, Weiwei Lu, Xinyuan Wu, Xuan Wang, Xiaojie Lu, Ming Yan, Xue‐Jing Zhang
Abstract
The photocatalyst-free electron donor-acceptor (EDA) complex photochemistry was deemed to expand the potential of photodriven radical chemistry. Here, we report a cross-coupling reaction of thianthrenium salt functionalized arenes and sodium sulfinates via a photopromoted single electron transfer (SET) process of an EDA complex. A series of biarylsulfones were obtained with high site-selectivity and reactivity. This mild and practical radical reaction could be applied on the bioactive and DNA-encoded molecules.
Topics & Concepts
ChemistryDNAMoleculeCombinatorial chemistryStereochemistryOrganic chemistryBiochemistrySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods