Visible light-mediated difluoromethylation/cyclization in batch and flow: scalable synthesis of CHF<sub>2</sub>-containing benzimidazo- and indolo[2,1-<i>a</i>]isoquinolin-6(5<i>H</i>)-ones
Al Hannam, Phinyada Kankraisri, Karan Ramdas Thombare, Prahallad Meher, Alexandre Jean, Stephen T. Hilton, Sandip Murarka, Stellios Arseniyadis
Abstract
)-ones through a visible light-mediated difluoromethylation/cyclization cascade. The method, which affords functionalized multifused N-heterocyclic scaffolds in moderate to high yields under mild reaction conditions, is also easily scalable using low-cost 3D printed photoflow reactors.
Topics & Concepts
ChemistryCombinatorial chemistryScalabilityFlow chemistryComputer scienceOrganic chemistryCatalysisDatabaseFluorine in Organic ChemistryRadical Photochemical Reactions