A Unique Multifunctional Nanoenzyme Tailored for Triggering Tumor Microenvironment Activated NIR‐II Photoacoustic Imaging and Chemodynamic/Photothermal Combined Therapy
Shulong Wang, Jingjin Zhao, Liangliang Zhang, Chaobang Zhang, Zhidong Qiu, Shulin Zhao, Yong Huang, Hong Liang
Abstract
Abstract The accurate diagnosis and targeted therapy of malignant tumors face significant challenges. To address these, an oxidized molybdenum polyoxometalate‐copper nanocomposite ( Ox ‐POM@Cu) is designed and synthesized here. The doping with Cu determines the formation of oxygen vacancies, which can increase the carrier concentration in Ox ‐POM@Cu, accelerate electron transfer, and enhance the redox activity, thus playing an efficient catalytic role. The nanocomposite presents unique enzymatic functions characterized by a multielement catalytic activity in the tumor microenvironment (TME). In addition, it can be employed as an NIR‐II photoacoustic imaging (PAI) probe and cancer therapy agent. First, it participates in a redox reaction with glutathione (GSH) in tumor tissues, activates the PAI and photothermal therapy functions via NIR‐II irradiation, and depletes the GSH supply in cancerous cells. Subsequently, it catalyzes a Fenton‐like reaction with H 2 O 2 in tumor tissues to form hydroxyl radicals, thereby performing a chemodynamic therapy function. The findings show that the developed nanoenzyme is very efficient in the diagnosis and treatment of malignant tumors. This work not only provides a new strategy for the design of TME‐induced NIR‐II PAI but also presents new insights into enhanced cancer therapy.