Increased Cleavage of Japanese Encephalitis Virus prM Protein Promotes Viral Replication but Attenuates Virulence
Junyao Xiong, Mengxue Yan, Shuo Zhu, Bohan Zheng, Ning Wei, Lingen Yang, Youhui Si, Shengbo Cao, Jing Ye
Abstract
Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis epidemics in Southeast Asia, affecting mostly children, with high morbidity and mortality. During the viral maturation process, prM is cleaved into M by the cellular endoprotease furin in the acidic secretory system.
Topics & Concepts
FurinVirologyVirulenceJapanese encephalitisVirusViral replicationMutantBiologyCleavage (geology)FlavivirusEncephalitisGeneGeneticsBiochemistryEnzymeFracture (geology)PaleontologyMosquito-borne diseases and controlViral Infections and VectorsPlant Virus Research Studies