Emilin 2 promotes the mechanical gradient of the cochlear basilar membrane and resolution of frequencies in sound
Ian J. Russell, Victoria A. Lukashkina, Snezana Levic, Young‐Wook Cho, Andrei N. Lukashkin, Lily Ng, Douglas Forrest
Abstract
mice displayed broadened mechanical and neural frequency tuning with multiple response peaks that are shifted to lower frequencies than normal. Thus, emilin 2 confers a stiffness gradient on the BM that is critical for accurate frequency resolution.
Topics & Concepts
Basilar membraneSound (geography)AcousticsResolution (logic)CochleaInner earPhysicsBiologyAnatomyComputer scienceArtificial intelligenceHearing, Cochlea, Tinnitus, GeneticsHearing Loss and RehabilitationAcoustic Wave Phenomena Research