Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d
Namit Chaudhary, Lisa N. Kasiewicz, Alexandra N. Newby, Mariah L. Arral, Saigopalakrishna S. Yerneni, Jilian R. Melamed, Samuel T. LoPresti, Katherine C. Fein, Daria M. Strelkova Petersen, Sushant Kumar, Rahul Purwar, Kathryn A. Whitehead
Topics & Concepts
ReceptorChemistryImmune systemAmine gas treatingTLR4BiochemistryBiologyImmunologyOrganic chemistryImmune Response and InflammationImmunotherapy and Immune ResponsesRNA Interference and Gene Delivery