Nickel-catalyzed cyclization of 1,7-enynes for the selective synthesis of dihydrocyclobuta[<i>c</i>]quinolin-3-ones and benzo[<i>b</i>]azocin-2-ones
Li Qiao, Yun Cai, Yuanyuan Hu, Hongwei Jin, Fen‐Er Chen, Yunkui Liu, Bingwei Zhou
Abstract
]azocin-2-ones. The two varied products could be easily obtained by tuning the reaction temperature. This reaction features easy temperature-control, high efficiency, and gram-scale synthesis.
Topics & Concepts
CatalysisNickelCombinatorial chemistryChemistryReaction conditionsMedicinal chemistryOrganic chemistryCatalytic Alkyne ReactionsSynthetic Organic Chemistry MethodsCyclopropane Reaction Mechanisms