A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma
Vanaja Konduri, Sujith K. Joseph, Tiara T. Byrd, Zeid Nawas, Jonathan Vazquez‐Perez, Colby J. Hofferek, Matthew M. Halpert, Dongliang Liu, Zhengdong Liang, Yunyu Baig, Vita S. Salsman, Damilola Oyewole-Said, Anna Tsimelzon, Briana A. Burns, Changyi Chen, Jonathan M. Levitt, Qizhi Yao, Nabil Ahmed, Meenakshi Hegde, William K. Decker
Abstract
pancreatic ductal adenocarcinoma, exhibiting elevated expression of granzymes and reduced expression of exhaustion markers. These data suggest that this T cell subset presents an opportunity to improve CAR T cell therapy for the treatment of solid tumors.
Topics & Concepts
Cytotoxic T cellEffectorPancreatic ductal adenocarcinomaCancer researchCellT cellBiologyImmunologyMedicinePancreatic cancerImmune systemInternal medicineCancerIn vitroGeneticsBiochemistryCAR-T cell therapy researchNanowire Synthesis and ApplicationsAdvancements in Semiconductor Devices and Circuit Design