Ruthenium(II)‐Catalyzed C‐H Annulation of Aromatic Acids with Alkynes Using Air as the Sole Oxidant in Water
Jiaping Wu, Baiyang Qian, Yanfei Liu, Yongjia Shang
Abstract
Abstract A facile synthesis of isocoumarin and α ‐pyrones derivatives by Ru(II)‐catalyzed oxidative annulation of aromatic acids and alkynes is reported. This reaction could undergo smoothly in water by use of air as the sole oxidant and accomplishes with the tolerance of a wide range of functional groups. Additionally, the oxidative cyclization of benzoic acid and acrylate is also achieved in the same conditions to furnish the isobenzofuran‐1(3 H )‐one scaffold.
Topics & Concepts
AnnulationIsocoumarinChemistryCatalysisIsobenzofuranBenzoic acidOxidative phosphorylationPhthalideOrganic chemistryAcrylateRutheniumIsocoumarinsCombinatorial chemistryBiochemistryMonomerPolymerCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Alkyne Reactions