OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3
Xiaoyu Sun, Shuhong Chen, Ying Zhao, Tong Wu, Zheyu Zhao, Wu Luo, Jibo Han, Zimin Fang, Bozhi Ye, Gang Cao, Shengbin Huang, Guang Liang
Abstract
Ovarian tumor domain-containing protein 6 A (OTUD6A) knockout mice are protected against angiotensin II-induced kidney dysfunction and fibrosis. OTUD6A promotes pathological kidney remodeling and dysfunction by deubiquitinating signal transducer and activator of transcription 3 (STAT3). OTUD6A binds to and removes K63-linked-ubiquitin chains of STAT3 to promote its phosphorylation and activation, and subsequently enhances kidney fibrosis.
Topics & Concepts
Deubiquitinating enzymeKidneyFibrosisUbiquitinCancer researchSTAT3Acute kidney injuryAngiotensin IIPathophysiologyMedicineBiologyPhosphorylationEndocrinologyCell biologyPathologyInternal medicineGeneReceptorBiochemistryRenal cell carcinoma treatmentChronic Kidney Disease and DiabetesRenal and related cancers