Cardiogenic shock: do we need a paradigm shift?
Thomas F. Lüscher, Hölger Thiele
Abstract
The paradigm shift in the management of cardiogenic shock: moving from pure mechanical left ventricular unloading to neurohumoral and anti-inflammatory blockade with or without left ventricular mechanical assistance (red arrow). CI, confidence interval; iNOS, inducible nitric oxide synthase; LV, left ventricular; LVEDP, left ventricular end-diastolic pressure; mAFP, microaxial flow pump; NO, nitric oxide; RAAS, renin-angiotensin-aldosterone system; SIRS, systemic inflammatory response syndrome.
Topics & Concepts
MedicineCardiogenic shockShock (circulatory)Intensive care medicineCardiologyInternal medicineMyocardial infarctionMechanical Circulatory Support DevicesCardiac Arrest and ResuscitationCardiac Structural Anomalies and Repair