Association of E484K Spike Protein Mutation With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Vaccinated Persons: Maryland, January–May 2021
Kenneth A. Feder, Ami B. Patel, Venkata R. Vepachedu, Catherine Dominguez, Eric N. Keller, Liore Klein, Curi Kim, Tim Blood, Judie Hyun, Thelonious W. Williams, Katherine A. Feldman, Heba H. Mostafa, C. Paul Morris, Jacques Ravel, Monique Duwell, David Blythe, Robert A. Myers
Abstract
Among 9048 people infected with SARS-CoV-2 between January and May 2021 in Maryland, in regression-adjusted analysis, SARS-CoV-2 viruses carrying the spike protein mutation E484K were disproportionately prevalent among persons infected after full vaccination against COVID-19 compared with infected persons who were not fully vaccinated (aOR, 1.96; 95% CI: 1.36-2.83).
Topics & Concepts
MedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Spike ProteinVirologyCoronavirusVaccinationCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakBetacoronavirusRespiratory systemMutationImmunologyOutbreakInternal medicineBiologyGeneDiseaseGeneticsInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesViral gastroenteritis research and epidemiology