Novel, selective acrylamide linked quinazolines for the treatment of double mutant EGFR-L858R/T790M Non-Small-Cell lung cancer (NSCLC)
Rahul Pawara, Iqrar Ahmad, Deepika Nayak, Shivani S. Wagh, Avinash Wadkar, M. Azim Ansari, Sateesh Belamkar, Sanjay J. Surana, Chanakya Nath Kundu, Chandragauda Patil, Harun Patel
Topics & Concepts
T790MChemistryGefitinibEpidermal growth factor receptorEGFR inhibitorsAfatinibMTT assayCytotoxicityCell culturePharmacologyCancer researchCell growthBiochemistryIn vitroReceptorBiologyGeneticsQuinazolinone synthesis and applicationsLung Cancer Treatments and MutationsCancer therapeutics and mechanisms