Nickel-catalyzed reductive coupling of unactivated alkyl bromides and aliphatic aldehydes
Cole L. Cruz, John Montgomery
Abstract
Aliphatic aldehydes and alkyl bromides are reductively coupled using nickel catalysis. A BiOX ligand and 1,5-hexadiene paired with a silyl chloride and Mn as the terminal reductant are important features of the process.
Topics & Concepts
AlkylCatalysisChemistryNickelReductive eliminationYield (engineering)Oxidative additionSilylationBromideLigand (biochemistry)StoichiometryCombinatorial chemistryCoupling reactionOrganic chemistryMaterials scienceMetallurgyBiochemistryReceptorCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsOxidative Organic Chemistry Reactions