The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon
Xiao-Lian Yang, Wang Gan, Jinyan Xie, Han Li, Shuxian Chen, Wei Liu, Shu Zhu
Abstract
While cumulative data indicate that indigenous commensal bacteria can facilitate enteric virus infection, little is known regarding whether intestinal microbes have a protective role in antagonizing enteric systemic infection by modulating host innate immunity. Although accumulating literature has pointed out that the microbiota has a fundamental impact on host systemic antiviral innate immune responses mediated by type I interferon (IFN), only a few specific commensal bacteria species have been revealed to be capable of regulating IFN-I and ISG expression, not to mention the underlying mechanisms.
Topics & Concepts
Innate immune systemEnteric virusMicrobiomeImmunologyInterferonImmunityMicrobiologyHost (biology)VirologyBiologyVirusGut microbiomeMedicineImmune systemGut floraBioinformaticsEcologyViral gastroenteritis research and epidemiologyClostridium difficile and Clostridium perfringens researchGut microbiota and health