Genomics-driven discovery of chiral triscatechol siderophores with enantiomeric Fe(<scp>iii</scp>) coordination
Parker R. Stow, Zachary L. Reitz, Timothy C. Johnstone, Alison Butler
Abstract
Synthesis and genome mining leverage access to diastereomers of the siderophore cyclic trichrysobactin. Computational modeling and CD spectroscopy address effects that ligand-based stereochemistry exerts on the configuration at Fe( iii ).
Topics & Concepts
SiderophoreDiastereomerEnantiomerLeverage (statistics)ChemistryStereochemistryCoordination complexCombinatorial chemistryGenomicsComputational biologyGenomeLigand (biochemistry)BiologyBiochemistryOrganic chemistryGeneComputer scienceReceptorMetalMachine learningPhotosynthetic Processes and MechanismsLegume Nitrogen Fixing SymbiosisGenomics and Phylogenetic Studies