New quinoxaline-2(1<i>H</i>)-ones as potential VEGFR-2 inhibitors: design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations
Reda G. Yousef, Helmy Sakr, Ibrahim H. Eissa, Ahmed B. M. Mehany, Ahmed M. Metwaly, Mostafa A. Elhendawy, Mohamed M. Radwan, Mahmoud A. ElSohly, Hamada S. Abulkhair, Khaled El‐Adl
Abstract
Eleven new quinoxaline derivatives were designed and synthesized as modified VEGFR-2 inhibitors of our previous work.
Topics & Concepts
ChemistryQuinoxalineDocking (animal)VEGF receptorsStereochemistryCombinatorial chemistryComputational biologyCancer researchOrganic chemistryMedicineNursingBiologySynthesis and Biological EvaluationSynthesis and biological activitySynthesis and Reactions of Organic Compounds