Shape-based separation of drug-treated <i>Escherichia coli</i> using viscoelastic microfluidics
Tianlong Zhang, Hangrui Liu, Kazunori Okano, Tao Tang, Kazuki Inoue, Yoichi Yamazaki, Hironari Kamikubo, Amy K. Cain, Yo Tanaka, David W. Inglis, Yoichiroh Hosokawa, Yalikun Yaxiaer, Ming Li
Abstract
with a higher AR (AR > 1.5) are driven to the side outlets. Further, we demonstrate that the separation performance of the viscoelastic microfluidic device is influenced by two main factors: sheath-to-sample flow rate ratio and the concentration of poly-ethylene-oxide (PEO). To the best of our knowledge, this is the first report on shape-based separation of a single species of cells smaller than 4 μm by microfluidics.
Topics & Concepts
MicrofluidicsViscoelasticityEscherichia coliChemistrySeparation (statistics)DrugChromatographyMaterials scienceNanotechnologyBiologyComputer scienceComposite materialBiochemistryPharmacologyGeneMachine learningMicrofluidic and Bio-sensing TechnologiesMicrofluidic and Capillary Electrophoresis ApplicationsInnovative Microfluidic and Catalytic Techniques Innovation