Advances in Mendelian Randomization Studies of Obesity Over the Past Decade: Uncovering Key Genetic Mechanisms
Xinyue Lu, Lei Ji, Dong Chen, Xiaoyang Lian, Mengqian Yuan
Abstract
have been identified as potential therapeutic targets. Current challenges include instrument strength, pleiotropy, population stratification, and the external validity of GWAS data. Future research that integrates multi-ancestry GWAS, functional validation, and multi-omics approaches may further enhance the utility of Mendelian randomization. MR provides a robust genetic framework for elucidating obesity's causal effects and informing targeted interventions and personalized treatment strategies.
Topics & Concepts
Mendelian randomizationGenome-wide association studyConfoundingPleiotropyDiseasePopulationCausal inferenceMedicineBioinformaticsBiologyGeneticsSingle-nucleotide polymorphismGenetic variantsEnvironmental healthPathologyGenePhenotypeGenotypeGenetic Associations and EpidemiologyEpigenetics and DNA MethylationLiver Disease Diagnosis and Treatment