Non‐Diazo C−H Insertion Approach to Cyclobutanones through Oxidative Gold Catalysis
Zhitong Zheng, Youliang Wang, Xu Ma, Yuxue Li, Liming Zhang
Abstract
Abstract Cyclobutanones are synthetically versatile compounds that often require extensive effort to access. Herein, we report a facile synthesis of cyclobutanones based on the C(sp 3 )−H insertion chemistry of oxidatively generated gold carbenes. Various cyclobutanones were obtained in synthetically useful yields from substrates with minimal structural prefunctionalization. This discovery reveals new synthetic utilities of gold‐catalyzed oxidative transformations of alkynones.
Topics & Concepts
Oxidative phosphorylationDiazoChemistryCatalysisCombinatorial chemistryOxidative additionOrganic chemistryBiochemistryCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis