EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells
Neele Schumacher, Ilka Thomsen, Florian Brundert, Václav Hejret, Stefan Düsterhöft, Boris Tichý, Dirk Schmidt‐Arras, Matthias Voß, Stefan Rose‐John
Topics & Concepts
Cell biologyGlycoprotein 130Epidermal growth factor receptorMAPK/ERK pathwaySignal transductionDownregulation and upregulationCytokineInterleukin-6 receptorReceptorChemistryBiologyCancer researchInterleukinImmunologyBiochemistrySTAT3GeneHER2/EGFR in Cancer ResearchCytokine Signaling Pathways and InteractionsInflammatory mediators and NSAID effects