Organocatalytic enantioselective [2 + 2] cycloadditions towards chiral fused α-trifluoromethyl azetidines
S. Zhang, Xingjie Luo, Siqiang Fang, Jia‐Hong Wu, Jianke Pan, Zhipeng Xu, Tianli Wang
Abstract
Herein, we report straightforward access to chiral fused α-trifluoromethyl azetidines via organocatalytic asymmetric [2 + 2] cycloadditions. This method is characterized by mild reaction conditions, high efficiency, and excellent stereoselectivities.
Topics & Concepts
TrifluoromethylChemistryEnantioselective synthesisCombinatorial chemistryOrganic chemistryCatalysisAlkylFluorine in Organic ChemistrySynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms